Felix Assign provides automatic and semi-automatic capabilities for NMR spectral assignment of biological macromolecules, encompassing all the stages of spin system detection, spin system identification, resonance and crosspeak assignment, and restraint generation. A broad range of spectra can be analyzed, from homonuclear 2D spectra to heteronuclear double- and triple-resonance, 3D and 4D spectra using methods developed in collaboration with Dr. R. Kaptein (Utrecht, Netherlands)2 and Dr. D. Marion (Grenoble, France)3.









The sophisticated algorithms (such as those based on fuzzy algebra and global optimization for spin system identification and sequential assignments, as well as the great variety of manual tools for generating overlaid spectra, correlated frames, tiles, and strip plots) make Felix Assign invaluable during the complex task of spin system assignment. Felix Assign can literally save years of effort by tracking, managing, and automating the assignment process.

Highlights
•  Spin system detection and sequential assignment for numerous experiments:

 
2D & 3D Homonuclear - 2D COSY/TOCSY/NOESY
- 3D TOCSY-TOCSY/TOCSY-NOESY/NOESY-NOESY
2D & 3D Double Resonance - 2D 15N HSQC
- 3D 15N HSQC-TOCSY
- 3D HCCH-TOCSY
3D Triple Resonance - HNCO/HNCA/HN(CO)CA
- CBCANH/CBCA(CO)NH
- HNCO/CBCANH/CBCACO(N)H
- HNHA/HNCACB/CBCA(CO)NH
Triple Resonance - HNCAHA/HN(CO)CAHA


  
   
  
   
  
   
   4D  
•  Ability for user to define assignment protocol if alternative experiments performed
•  Flexible overlay of spectra
•  Automated and manual NOE crosspeak assignment for:
   - 2D NOESY
   - 3D NOESY-NOESY
   - 3D and 4D heteronuclear edited NOESY spectra
•  Generation of restraints that can be read by Insight II’s NMR Refine DGII, NMR Refine Advanced,NMR X-PLOR, and CNX-NMR

 
   
   •  Product Overview
   • 
Felix 2D/ND
   • 
Modules
        Felix 2D/ND
        Felix Assign
        Felix Autoscreen
        Felix Model
   •  Case Studies
        Spectral Assignment
        Spectral Processing & Analysis
        Structure Calculation & Analysis

   •  System Requirements
   •  How to Try/Buy Felix 
         
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